long-term results of stereotactic brachytherapy (temporary 125iodine seeds) for the treatment of low-grade astrocytoma (grade ii)

conclusions the stereotactic brachytherapy for patients with circumscribed and relatively small size tumors appears to be a safe, feasible, and minimally-invasive treatment. results thirteen patients were male and 16 were female, with the median age of 29 years (range, 2.5 – 64 years). the median follow-up was 95 (range, 6 – 240) months. based on pignatti classification, 10 patients were at low- and 19 patients at high-risk. the median overall as well as progression-free survivals for patients were 135 months (95% confidence interval: 76 – 194) and 96 months (95% confidence interval: 1 – 199), respectively. five- and 10-year progression-free survivals were 41.4 % and 34.5 %, respectively, and the 5- and 10-year overall survivals were 65.5 % and 44.8%, respectively. progression-free survival was not significantly higher in smaller size tumors (p = 0.224), nor for spherical versus non-spherical tumors (p = 0.307). there was no treatment-related morbidity after stereotactic brachytherapy, and no radiogenic complications occurred during the follow-up period. mortality due to tumor progression occurred in 4 patients (14%), and 11 patients were alive at the last follow-up. objectives the purpose of this study was to evaluate disease control and survival after stereotactic brachytherapy in patients with circumscribed and relatively small size tumors. materials and methods a retrospective review of 29 patients, treated between 1991 and 2011, was conducted to evaluate survival, complications, and local disease control after stereotactic brachytherapy. they belonged to a larger group of 48 cases with low-grade gliomas, treated with stereotactic brachytherapy. the demographic and clinical characteristics in patients including age, sex, and survival time were extracted from records. background treatment of low-grade astrocytoma (who grade ii) (lga ii) remains a challenge. there is limited information regarding the long-term effects of stereotactic brachytherapy (sbt) (temporary 125iodine seeds) on patients with lga ii.